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The “dirt” in the lung from cigarette smoking (and presumably from other forms of pollution as well) had caused the immune system to go into hyper-response, in the form of sending in more and more macrophages to try to repair the damage, a situation that could not go on forever without some kind of mutation or “mistake” occurring in the DNA of these cells.

Source: Molecules of Emotion: The Science Behind Mind-Body Medicine by Candace B. Pert | link

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